Proven in practice, validated in science

May 28, 2024

Expanding the Treatable Imaging Profile in Patients With Large Ischemic Stroke: Subanalysis From a Randomized Clinical Trial

RAPID perfusion software used. In this prespecified analysis of a randomized clinical trial involving patients with large ischemic strokes, patients with an estimated core volume of up to 128 mL on diffusion-weighted imaging benefit from EVT.

February 24, 2024

Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial

RAPID used to select patients for SELECT2. In patients with ischaemic stroke due to a proximal occlusion and large core, thrombectomy plus medical care provided a significant functional outcome benefit compared with medical care alone at 1-year follow-up.

February 22, 2024

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection

Rapid CT Perfusion (CTP) and Rapid MRI Perfusion Maps were leveraged for all patient selection. TIMELESS is the first study to show that an intravenous thrombolytic can be given up to 24 hours after LKW without an increase in brain hemorrhage.

January 1, 2024

Alberta Stroke Program Early Computed Tomography Score, Infarct Core Volume, and Endovascular Therapy Outcomes in Patients With Large Infarct: A Secondary Analysis of the ANGEL-ASPECT Trial

Endovascular therapy (EVT) demonstrated better outcomes compared with medical management in recent randomized clinical trials (RCTs) of patients with large infarct. RAPID used for ANGEL-ASPECT.

April 6, 2023

Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct

Infarct-core volumes as assessed on diffusion-weighted imaging at baseline and during follow-up were calculated with the use of RAPID software, version 5.0.4 (iSchemaView). In a trial conducted in China, patients with large cerebral infarctions had better outcomes with endovascular therapy administered within 24 hours than with medical management alone but had more intracranial hemorrhages.

August 1, 2023

Elevated Hypoperfusion Intensity Ratio (HIR) observed in patients with a large vessel occlusion (LVO) presenting in the evening

This retrospective analysis suggests that HIR is significantly higher in the evening, indicating poorer collateral activation which may lead to larger core volumes in these patients. RAPID HIR calculation used.

November 21, 2023

Factors Associated With Fast Early Infarct Growth in Patients With Acute Ischemic Stroke With a Large Vessel Occlusion

The HIR is the primary factor associated with fast infarct progression, regardless of imaging modality. These results have implication for neuroprotection trial design, as well as informing triage decisions at primary stroke centers. RAPID used to calculate HIR.

November 24, 2023

Performance of RAPID noncontrast CT stroke platform in large vessel occlusion and intracranial hemorrhage detection

Key NCCT Stroke paper. "The RAPID NCCT Stroke platform demonstrates superior performance to radiologists for detecting LVO from a NCCT. Use of this software platform could lead to earlier LVO detection and expedited transfer of these patients to a thrombectomy capable center."

December 1, 2023

Pretreatment brain CT perfusion thresholds for predicting final infarct volume in distal medium vessel occlusions

Use of RAPID for DMVOs.

December 1, 2023

Decreasing false-positive detection of intracranial hemorrhage (ICH) using RAPID ICH 3

The automated software correctly identified 453/463 ICH-positive cases and 416/418 ICH-negative cases, resulting in a sensitivity of 97.84% and specificity 99.52%, positive predictive value 99.56%, and negative predictive value 97.65% for ICH detection.

October 1, 2022

RAPID Aneurysm: Artificial intelligence for unruptured cerebral aneurysm detection on CT angiography

This study utilized RAPID Aneurysm to determine its performance and accuracy in the detection of cerebral aneurysms on CTA.

September 30, 2022

Artificial intelligence aneurysm measurement tool finds growth in all aneurysms that ruptured during conservative management

This is a retrospective study using an AI-enabled aneurysm measurement tool, Rapid Aneurysm, to calculate intracranial aneurysms' volume and surface area.

October 26, 2022

Thrombectomy Outcomes With General vs Non-general Anesthesia: A Pooled, Patient-Level Analysis From the EXTEND-IA Trials and SELECT Study

October 19, 2022

Hypoperfusion intensity ratio and CBV index as predictive parameters to identify underlying intracranial atherosclerotic stenosis in endovascular thrombectomy

June 23, 2022

Intravenous tPA (Tissue-Type Plasminogen Activator) Correlates With Favorable Venous Outflow Profiles in Acute Ischemic Stroke

June 7, 2022

The Cerebral Collateral Cascade

January 1, 2022

Perfusion Imaging Collateral Scores Predict Infarct Growth in Non-Reperfused DEFUSE 3 Patients

November 4, 2022

Sex differences in imaging and clinical characteristics of patients from the WAKE-UP trial

November 23, 2022

Cerebral perfusion imaging predicts final infarct volume after basilar artery thrombectomy

January 12, 2021

High-Performance Automated Anterior Circulation CT Angiographic Clot Detection in Acute Stroke: A Multireader Comparison

Researchers confirmed the feasibility of fast, automated, high-performance detection of large vessel occlusions in acute stroke patients.

January 13, 2021

2020 Global AI-based Stroke Imaging and Diagnosis Company of the Year Award

This report from Frost & Sullivan explains why RapidAI was selected as its Global Company of the Year.

February 10, 2021

2020 Global Intelligent Imaging Analysis Systems Growth, Innovation & Leadership Frost Radar Award

This report from Frost & Sullivan explains why RapidAI won its Frost Radar Award for Growth, Innovation and Leadership

April 1, 2021

Impact of RapidAI mobile application on treatment times in patients with large vessel occlusion

This study concluded that use of the Rapid Mobile App helped reduce intrahospital treatment times for LVO patients.

April 13, 2021

Stroke Imaging Utilization According to Age and Severity during the COVID-19 Pandemic

The study used RapidAI data to show stroke imaging utilization decreased early in the pandemic but later recovered.

April 26, 2021

Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time

The study found found that the automatically calculated HIR value from Rapid CTP is a helpful predictor of clinical outcomes in stroke patients receiving EVT.

April 28, 2021

Positive predictive value and stroke workflow outcomes using automated vessel density (RAPID-CTA) in stroke patients: One year experience

Time to treatment was significantly lower and clinical outcomes were improved after deployment of Rapid CTA

July 28, 2021

Angiography Suite Cone-Beam Computed Tomography Perfusion Imaging in Large-Vessel Occlusion Patients Using Rapid Software

The technology would allow bypassing the emergency department for transferred large-vessel occlusion late-window patients.

October 1, 2021

Distal Medium Vessel Occlusions Can Be Accurately and Rapidly Detected Using Tmax Maps

July 26, 2021

Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset

December 10, 2021

Mechanical Thrombectomy Up to 24 Hours in Large Vessel Occlusions and Infarct Velocity Assessment

August 18, 2021

Automated Perfusion-Diffusion Magnetic Resonance Imaging in Childhood Arterial Ischemic Stroke

December 21, 2021

Perfusion Imaging Predicts Favorable Outcomes after Basilar Artery Thrombectomy

May 6, 2020

Thrombolysis before Thrombectomy — To Be or DIRECT-MT?

Editorial by RapidAI co-founder Dr. Gregory Albers on the article "Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke."

May 8, 2020

Collateral Effect of Covid-19 on Stroke Evaluation in the United States

In this letter to the editor of the New England Journal of Medicine, Dr. Greg Albers examines the impact of COVID-19 on stroke care.

December 22, 2020

Mismatch Profile Influences Outcome After Mechanical Thrombectomy

Researchers conclude that perfusion imaging profiles predict the clinical response to mechanical thrombectomy in the early time window.

December 1, 2020

Automated Cerebral Hemorrhage Detection Using RAPID

January 28, 2019

Association of Thrombectomy with Stroke Outcomes Among Patient Subgroups

In this secondary analysis of a randomized clinical trial, endovascular therapy resulted in in better functional outcome among a broad patient population.

February 5, 2019

Automated Calculation of the Alberta Stroke Program Early CT Score: Feasibility and Reliability

In candidates for thrombectomy, the Alberta Stroke Program Early CT score calculated with automated software showed better agreement with a predefined consensus score than with expert human readers, especially for scans obtained between 1–4 hours from symptom onset.

April 1, 2019

Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis–A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials

In randomized clinical trials, mechanical thrombectomy (MT) was proved to be a highly effective treatment of acute ischemic stroke which improved clinical outcomes.

April 12, 2019

Outcomes of Thrombectomy in Transferred Patients With Ischemic Stroke in the Late Window

In this secondary analysis of a randomized clinical trial, transfer and direct patients had comparable rates of functional independence and similar treatment effect with endovascular thrombectomy as well as similar symptomatic intracranial hemorrhage and mortality.

March 29, 2019

Persistent Target Mismatch Profile >24 Hours After Stroke Onset in DEFUSE 3

Concluded that about 20% of patients with a middle cerebral artery or internal carotid artery occlusion who present in an extended time window and are not treated with thrombectomy have a persistent mismatch for at least an additional 24 hours.

February 6, 2019

Ischemic Core and Hypoperfusion Volumes Correlate With Infarct Size 24 Hours After Randomization in DEFUSE 3

Concluded that the union of the irreversibly injured ischemic core and persistently hypoperfused tissue volumes, as identified by computed tomography perfusion or magnetic resonance diffusion weighted imaging/perfusion, predicted infarct volume at 24 hours after randomization in DEFUSE 3 patients.

February 6, 2019

DEFUSE 3 Non-DAWN Patients

Concluded that patients with pretreatment core infarct volumes <70 mL but too large for inclusion by DAWN criteria demonstrate benefit from endovascular therapy.

May 9, 2019

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited to within 4.5 hours after the onset of symptoms. RAPID was the imaging system used in trials that have suggested the treatment window may be extended in patients who are shown to have ischemic but not yet infarcted brain tissue on imaging.

September 9, 2019

Automated Detection of Intracranial Large Vessel Occlusions on Computed Tomography Angiography

The study assessed the accuracy and speed of a commercially available fully automated LVO-detection algorithm (RAPID CTA) in a cohort of patients presenting to a regional hospital with suspected stroke. RAPID CTA had very high sensitivity and negative predictive value for LVO detection with fast processing times, suggesting that it can be used in the emergent setting as a screening tool to alert radiologists and expedite formal diagnosis.

September 10, 2019

Automated Calculation of Alberta Stroke Program Early CT Score

The study compared the Alberta Stroke Program Early CT Score (ASPECTS), calculated using a machine learning-based automatic software tool...

February 18, 2018

CT Profile Flags Stroke Patients Who May Have More Time

Stroke patients identified with computed tomography (CT) perfusion as having a distinctive neurologic profile show potential benefits from endovascular interventions well beyond the conventional 6-hour window, new research suggests.

January 4, 2018

Thrombectomy 6 to 24 Hours After Stroke with a Mismatch Between Deficit and Infarct

The effect of endovascular thrombectomy that is performed more than 6 hours after the onset of ischemic stroke is uncertain. Patients with a clinical deficit that is disproportionately severe relative to the infarct volume may benefit from late thrombectomy.

January 24, 2018

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association

The purpose of these guidelines is to provide an up-to-date comprehensive set of recommendations for clinicians caring for adult patients with acute arterial ischemic stroke in a single document. The intended audiences are prehospital care providers, physicians, allied health professionals, and hospital administrators. These guidelines supersede the 2013 guidelines and subsequent updates...

February 22, 2018

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

Endovascular thrombectomy for ischemic stroke 6 to 16 hours after a patient was last known to be well plus standard medical therapy resulted in better functional outcomes than standard medical therapy alone among patients with proximal middle-cerebral-artery or internal-carotid-artery occlusion and a region of tissue that was ischemic but not yet infarcted...

March 5, 2018

Perfusion Imaging and Recurrent Cerebrovascular Events in Intracranial Atherosclerotic Disease or Carotid Occlusion

Large vessel disease stroke subtype carries the highest risk of early recurrent stroke. In this study we aim to look at the association between impaired perfusion and early stroke recurrence in patients with intracranial athero-sclerotic disease or total cervical carotid occlusion.

April 11, 2018

Can Diffusion- and Perfusion-weighted Imaging Alone Accurately Triage Anterior Circulation Acute Ischemic Stroke Patients to Endovascular Therapy?

Acute ischemic stroke (ais) patients who benefit from endovascular treatment have a large vessel occlusion (lVO), small core infarction, and salvageable brain. We determined if diffusion-weighted imaging (DWi) and perfusion-weighted imaging (PWi) alone can correctly identify and localize anterior circulation lVO and accurately triage patients to endovascular thrombectomy (eT).

June 28, 2018

Use of Imaging to Select Patients for Late Window Endovascular Therapy

The substantial clinical benefits of late window thrombectomy that were recently documented in the DAWN and DEFUSE 3 studies led to expansion of the treatment window for thrombectomy from 6 to 24 hours in the 2018 American Heart Association stroke guidelines.

August 25, 2018

Hypoperfusion Ratio Predicts Infarct Growth During Transfer for Thrombectomy

Automated assessment of collaterals

October 18, 2018

Late Window Paradox

Explaining the paradox by understanding stroke evolution

January 8, 2017

Changing the Face of the Stroke Stopwatch

Treatment for stroke is determined by the stopwatch. Missing the few hours that are the window of opportunity between stroke onset and the time of diagnosis make many patients ineligible for reperfusion therapy, because of concerns that treatment might be too risky or ineffective.

January 13, 2017

Predictive Value of RAPID Assessed Perfusion Thresholds on Final Infarct Volume in SWIFT PRIME (Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment)

We aimed to analyze the accuracy of various rCBV and rCBF thresholds for predicting the 27-hour infarct volume using RAPID automated analysis software from the SWIFT PRIME trial (Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment) data.

February 13, 2017

Computed Tomographic Perfusion Selection and Clinical Outcomes After Endovascular Therapy in Large Vessel Occlusion Stroke

Different imaging paradigms have been used to select patients for endovascular therapy in stroke. We sought to determine whether computed tomographic perfusion (CTP) selection improves endovascular therapy outcomes compared with noncontrast computed tomography alone.

March 24, 2017

A Multicenter Randomized Controlled Trial of Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke (DEFUSE 3)

Early reperfusion in patients experiencing acute ischemic stroke is effective in patients with large vessel occlusion. No randomized data are available regarding the safety and efficacy of endovascular therapy beyond 6 h from symptom onset.

May 2, 2017

Efficacy of Stent-Retriever Thrombectomy in Magnetic Resonance Imaging Versus Computed Tomographic Perfusion—Selected Patients in SWIFT PRIME Trial (Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke)

Patients with middle cerebral artery and distal carotid occlusions were randomized to treatment with tPA (tissue-type plasminogen activator) alone or tPA+stentriever thrombectomy.

May 4, 2017

Computed Tomographic Perfusion to Predict Response to Recanalization in Ischemic Stroke

We conducted a multicenter cohort study of consecutive acute stroke patients scheduled to undergo endovascular therapy within 90 minutes after a baseline CT perfusion.

August 12, 2017

Brain Ischemia: CT and MRI Techniques in Acute Ischemic Stroke

Computed tomography (CT) / CT angiography or magnetic resonance (MR) / MR angiography imaging are used to exclude stroke mimics and haemorrhage, to determine the cause and mechanism of stroke, to define the extension of brain infarct and to identify the arterial occlusion.

August 22, 2017

Relative Cerebral Blood Volume is Associated with Collateral Status and Infarct Growth in Stroke Patients in SWIFT PRIME

We aimed to evaluate how predefined candidate cerebral perfusion parameters correlate with collateral circulation status and to assess their capacity to predict infarct growth in patients with acute ischemic stroke (AIS) eligible for endovascular therapy. Patients enrolled in the SWIFT PRIME trial with baseline computed tomography perfusion (CTP) scans were included.

September 19, 2017

Referral Facility CT Perfusion Prior to Inter-facility Transfer in Patients Undergoing Mechanical Thrombectomy

We conducted a single-center retrospective of a prospectively maintained database of consecutive ischemic stroke patients transferred to our center for consideration of endovascular therapy.

May 3, 2016

MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theoretical Principles

International experts in the field demonstrate how perfusion and pharmacokinetic imaging can be effectively used to analyze medical conditions, helping you reach accurate diagnoses and monitor disease progression and response to therapy...

August 9, 2016

Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy

Single-institutional computed tomographic perfusion data from 147 mechanically recanalized acute ischemic stroke patients were post-processed.

November 15, 2016

Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes

We retrospectively assessed the impact of gradual truncation of the scan duration on acute ischemic lesion volume measurements.

April 17, 2015

Stent-Retriever Thrombectomy After Intravenous t-PA vs. t-PA Alone in Stroke

We randomly assigned eligible patients with stroke who were receiving or had received intravenous t-PA to continue with t-PA alone (control group) or to undergo endovascular thrombectomy with the use of a stent retriever within 6 hours after symptom onset (intervention group).

July 7, 2015

Relationships Between Imaging Assessments and Outcomes in Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke

We evaluated associations between imaging assessments (baseline mismatch profiles/ischemic core volumes and successful reperfusion) with imaging outcomes (27-hour infarct volume/growth) and clinical outcomes (modified Rankin Scale scores at 90 days).

February 11, 2015

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes.

August 27, 2015

A Benchmarking Tool to Evaluate Computer Tomography Perfusion Infarct Core Predictions Against a DWI Standard

We aim to optimize CTP core identification using a novel benchmarking tool. The benchmarking tool consists of an imaging library and a statistical analysis algorithm to evaluate the performance of CTP.

October 15, 2015

Ischemic Core and Hypoperfusion Volumes Predict Infarct Size in SWIFT PRIME.

Within the context of a prospective randomized trial (SWIFT PRIME), we assessed whether early imaging of stroke patients, primarily with computed tomography (CT) perfusion, can estimate the size of the irreversibly injured ischemic core and the volume of critically hypoperfused tissue. We also evaluated the accuracy of ischemic core and hypoperfusion volumes for predicting infarct volume in patients with the target mismatch profile.

October 1, 2012

MRI Profile and Response to Endovascular Reperfusion After Stroke (DEFUSE 2): a Prospective Cohort Study

We aimed to establish whether MRI can be used to identify patients who are most likely to benefit from endovascular reperfusion.

December 27, 2012

Early Diffusion-Weighted Imaging and Perfusion-Weighted Imaging Lesion Volumes Forecast Final Infarct Size in DEFUSE 2

This is a substudy of Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2); all patients with technically adequate MRI scans at 3 time points were included. Baseline DWI and early follow-up PWI lesion volumes were determined by the RAPID software program.

November 1, 2010

Real-time Diffusion-perfusion Mismatch Analysis in Acute Stroke

We developed the RApid processing of Perfusion and Diffusion (RAPID) for unsupervised, fully automated processing of perfusion and diffusion data for the purpose of expedited routine clinical assessment.