Good cerebral collateral circulation is associated with favorable functional outcomes following EVT. Can a comprehensive cerebral collateral cascade (CCC) analysis help predict clinical and radiological outcomes in patients treated with EVT?
A study by Dr. Tobias Djamsched Faizy and co-authors, published in Neurology, used multiparametric CT imaging to assess the CCC of LVO patients that underwent thrombectomy.
This retrospective, multicenter, cohort study included large vessel occlusion patients treated with thrombectomy at two comprehensive hospitals, University Medical Center, Hamburg-Eppendorf, Germany, and Standard University Hospital, between January 2013 and December 2019.
A favorable CCC profile can predict good functional outcomes in large vessel occlusion patients undergoing thrombectomy.
Patients with favorable CCC profiles had considerably lower final infarct volumes.
The perfusion images were analyzed with Rapid CTP.
Ischemic core was defined as tissue volume with at least 70% reduced cerebral blood flow relative to the healthy contralateral hemisphere.
The Alberta Stroke Program Early CT Score (ASPECTS) was determined on pre-treatment head non-contrast CT scans.
Study groups and key findings
There were 176 patients with a favorable CCC profile, 126 with an unfavorable CCC profile, and 345 with mixed CCC profiles.
In the last decade, several randomized clinical trials demonstrated the role of CT perfusion (CTP) in evaluating anterior circulation large vessel occlusion (LVO) patients eligible for endovascular thrombectomy (EVT).
Portugués | Español The last decade has brought significant advances in imaging technologies and endovascular thrombectomy (EVT) devices used to treat acute ischemic stroke. While many of these advanced technologies are used in stroke...
A retrospective, observational, clinical cohort study conducted by Melissa J Visser and co-authors showed that it is feasible to use Rapid’s automated perfusion-diffusion imaging software to determine the mismatch characteristics in...